Loss of renal SNX5 results in impaired IDE activity and insulin resistance in mice

AIMS/HYPOTHESIS: We hypothesised that renal sorting nexin 5 (SNX5) regulates the insulin-degrading enzyme (IDE) and, thus, circulating insulin levels. We therefore studied the dynamic interaction between SNX5 and IDE in human renal proximal tubule cells (hRPTCs), as well as in rat and mouse kidneys....

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Li, Fengmin, Yang, Jian, Villar, Van Anthony M., Asico, Laureano D., Ma, Xiaobo, Armando, Ines, Sanada, Hironobu, Yoneda, Minoru, Felder, Robin A., Jose, Pedro A., Wang, Xiaoyan
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342204/
https://ncbi.nlm.nih.gov/pubmed/29080975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4482-1
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