Sorting Nexin 1 Loss Results in D(5) Dopamine Receptor Dysfunction in Human Renal Proximal Tubule Cells and Hypertension in Mice

The peripheral dopaminergic system plays a crucial role in blood pressure regulation through its actions on renal hemodynamics and epithelial ion transport. The dopamine D5 receptor (D(5)R) interacts with sorting nexin 1 (SNX1), a protein involved in receptor retrieval from the trans-Golgi network....

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Autors principals: Villar, Van Anthony M., Jones, John Edward, Armando, Ines, Asico, Laureano D., Escano, Crisanto S., Lee, Hewang, Wang, Xiaoyan, Yang, Yu, Pascua-Crusan, Annabelle M., Palmes-Saloma, Cynthia P., Felder, Robin A., Jose, Pedro A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537009/
https://ncbi.nlm.nih.gov/pubmed/23152498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.428458
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