p90RSK Blockade Inhibits Dual BRAF and MEK Inhibitor-Resistant Melanoma by Targeting Protein Synthesis

Despite improvements in survival in metastatic melanoma with combined BRAF and mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor treatment, the overwhelming majority of patients eventually acquire resistance to both agents. Consequently, new targets for therapy in resi...

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Veröffentlicht in:J Invest Dermatol
Hauptverfasser: Theodosakis, Nicholas, Micevic, Goran, Langdon, Casey G., Ventura, Alessandra, Means, Robert, Stern, David F., Bosenberg, Marcus W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342201/
https://ncbi.nlm.nih.gov/pubmed/28599981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2016.12.033
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