BRAF inhibition decreases cellular glucose uptake in melanoma in association with reduction in cell volume

BRAF kinase inhibitors have dramatically impacted treatment of BRAF(V600E)(/)(K)-driven metastatic melanoma. Early responses assessed using [(18)F]fluorodeoxyglucose uptake-positron emission tomography (FDG-PET) have shown dramatic reduction of radiotracer signal within two weeks of treatment. Despi...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Theodosakis, Nicholas, Held, Matthew A., Marzuka-Alcala, Alexander, Meeth, Katrina M., Micevic, Goran, Long, Georgina V., Scolyer, Richard A., Stern, David F., Bosenberg, Marcus W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497841/
https://ncbi.nlm.nih.gov/pubmed/25948295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0080
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