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Enantioselective C2-alkylation of indoles via a redox-relay Heck reaction of 2-indole triflates

A palladium-catalyzed enantioselective redox-relay Heck reaction of 2-indole triflates and disubstituted alkenes is reported. This process combines readily-available indole triflates with a variety of alkenes to afford a range of indole derivatives bearing a stereocenter adjacent to C2. Enantioselec...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Race, Nicholas J., Yuan, Qianjia, Sigman, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342193/
https://ncbi.nlm.nih.gov/pubmed/30402891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201805416
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