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Investigating the Nature of Palladium Chain-Walking in the Enantioselective Redox-Relay Heck Reaction of Alkenyl Alcohols

[Image: see text] The mechanism of the redox-relay Heck reaction was investigated using deuterium-labeled substrates. Results support a pathway through a low energy palladium–alkyl intermediate that immediately precedes product formation, ruling out a tautomerization mechanism. DFT calculations of t...

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Detalles Bibliográficos
Publicado en:J Org Chem
Main Authors: Hilton, Margaret J., Xu, Li-Ping, Norrby, Per-Ola, Wu, Yun-Dong, Wiest, Olaf, Sigman, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275159/
https://ncbi.nlm.nih.gov/pubmed/25186804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo501813d
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