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Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex

Aberrant Hedgehog (HH) signaling leads to various types of cancer and birth defects. N-terminally palmitoylated HH initiates signaling by binding its receptor Patched-1 (PTCH1). A recent 1:1 PTCH1–HH complex structure visualized a palmitate-mediated binding site on HH, which was inconsistent with pr...

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Publicado en:Science
Autores principales: Qi, Xiaofeng, Schmiege, Philip, Coutavas, Elias, Li, Xiaochun
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6341491/
https://ncbi.nlm.nih.gov/pubmed/30139912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aas8843
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