Defective negative regulation of Toll-like receptor signaling leads to excessive TNF-α in myeloproliferative neoplasm

Patients with myeloproliferative neoplasms (MPN) have high levels of inflammatory cytokines, some of which drive many of the debilitating constitutional symptoms associated with the disease and may also promote expansion of the neoplastic clone. We report here that monocytes from patients with MPN h...

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Udgivet i:Blood Adv
Main Authors: Lai, Hew Yeng, Brooks, Stefan A., Craver, Brianna M., Morse, Sarah J., Nguyen, Thanh Kim, Haghighi, Nahideh, Garbati, Michael R., Fleischman, Angela G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2019
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6341195/
https://ncbi.nlm.nih.gov/pubmed/30647074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018026450
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