Proximal human FOXP3 promoter transactivated by NF-κB and negatively controlled by feedback loop and SP3

Forkhead box protein 3 (Foxp3) is indispensable for the development of CD4(+)CD25(+) regulatory T cells (Tregs). Here we analyzed three prominent evolutionary conserved regions (ECRs) upstream of the transcription start site of the human FOXP3 gene. We show that ECR2 and ECR3 fragments derived from...

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Vydáno v:Mol Immunol
Hlavní autoři: Eckerstorfer, Paul, Novy, Michael, Burgstaller-Muehlbacher, Sebastian, Paster, Wolfgang, Schiller, Herbert B., Mayer, Herbert, Stockinger, Hannes
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6340486/
https://ncbi.nlm.nih.gov/pubmed/20462637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2010.04.002
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