Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14–3-3η/NF-κB feedback loop

BACKGROUND: Multi-drug resistance (MDR) is one of the main obstacles for treatment of advanced/recurrent hepatocellular carcinoma (HCC). We have previously identified arsenic trioxide (ATO) as an effective metastasis/angiogenesis inhibitor in HCC. Here, we further found that MDR-HCC cells were more...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Qiu, Yongxin, Dai, Yi, Zhang, Chi, Yang, Ye, Jin, Ming, Shan, Wenqi, Shen, Jian, Lu, Ming, Tang, Zhaoyang, Ju, Liang, Wang, Yuting, Jiao, Ruonan, Xia, Yunwei, Huang, Guangming, Yang, Lihua, Li, Yuan, Zhang, Jianping, Wong, Vincent Kam Wai, Jiang, Zhihong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302299/
https://ncbi.nlm.nih.gov/pubmed/30572915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-1005-y
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