Reversal of sorafenib resistance in hepatocellular carcinoma: epigenetically regulated disruption of 14-3-3η/hypoxia-inducible factor-1α

Sorafenib resistance is one of the main obstacles to the treatment of advanced/recurrent hepatocellular carcinoma (HCC). Here, sorafenib-resistant HCC cells and xenografts in nude mice were used as experimental models. A cohort of patients with advanced recurrent HCC who were receiving sorafenib the...

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Bibliografiska uppgifter
I publikationen:Cell Death Discov
Huvudupphovsmän: Qiu, Yongxin, Shan, Wenqi, Yang, Ye, Jin, Ming, Dai, Yi, Yang, Hanyu, Jiao, Ruonan, Xia, Yunwei, Liu, Qinqiang, Ju, Liang, Huang, Guangming, Zhang, Jianping, Yang, Lihua, Li, Lei, Li, Yuan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642098/
https://ncbi.nlm.nih.gov/pubmed/31341646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-019-0200-8
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