Conformational Differences between Functional Human Immunodeficiency Virus Envelope Glycoprotein Trimers and Stabilized Soluble Trimers

Binding to the receptor CD4 triggers entry-related conformational changes in the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer, (gp120/gp41)(3). Soluble versions of HIV-1 Env trimers (sgp140 SOSIP.664) stabilized by a gp120-gp41 disulfide bond and a change (I559P) in...

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Udgivet i:J Virol
Main Authors: Castillo-Menendez, Luis R., Nguyen, Hanh T., Sodroski, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Structure and Assembly
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6340038/
https://ncbi.nlm.nih.gov/pubmed/30429345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01709-18
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