Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

Hepatocellular carcinomas (HCC) exhibit distinct promoter hypermethylation patterns, but the epigenetic regulation and function of transcriptional enhancers remain unclear. Here, our affinity- and bisulfite-based whole-genome sequencing analyses reveal global enhancer hypomethylation in human HCCs....

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Xiong, Lei, Wu, Feng, Wu, Qiong, Xu, Liangliang, Cheung, Otto K., Kang, Wei, Mok, Myth T., Szeto, Lemuel L. M., Lun, Cheuk-Yin, Lung, Raymond W., Zhang, Jinglin, Yu, Ken H., Lee, Sau-Dan, Huang, Guangcun, Wang, Chiou-Miin, Liu, Joseph, Yu, Zhuo, Yu, Dae-Yeul, Chou, Jian-Liang, Huang, Wan-Hong, Feng, Bo, Cheung, Yue-Sun, Lai, Paul B., Tan, Patrick, Wong, Nathalie, Chan, Michael W., Huang, Tim H., Yip, Kevin Y., Cheng, Alfred S., To, Ka-Fai
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338783/
https://ncbi.nlm.nih.gov/pubmed/30659195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08245-z
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