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Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
Hepatocellular carcinomas (HCC) exhibit distinct promoter hypermethylation patterns, but the epigenetic regulation and function of transcriptional enhancers remain unclear. Here, our affinity- and bisulfite-based whole-genome sequencing analyses reveal global enhancer hypomethylation in human HCCs....
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6338783/ https://ncbi.nlm.nih.gov/pubmed/30659195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08245-z |
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