Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis

Although a combination of genomic and epigenetic alterations are implicated in the multistep transformation of normal squamous esophageal epithelium to Barrett esophagus, dysplasia, and adenocarcinoma, the combinatorial effect of these changes is unknown. By integrating genome-wide DNA methylation,...

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Detalhes bibliográficos
Main Authors: Alvarez, Hector, Opalinska, Joanna, Zhou, Li, Sohal, Davendra, Fazzari, Melissa J., Yu, Yiting, Montagna, Christina, Montgomery, Elizabeth A., Canto, Marcia, Dunbar, Kerry B., Wang, Jean, Roa, Juan Carlos, Mo, Yongkai, Bhagat, Tushar, Ramesh, K. H., Cannizzaro, Linda, Mollenhauer, J., Thompson, Reid F., Suzuki, Masako, Meltzer, Stephen, Melnick, Ari, Greally, John M., Maitra, Anirban, Verma, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069107/
https://ncbi.nlm.nih.gov/pubmed/21483804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001356
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