Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis

Although a combination of genomic and epigenetic alterations are implicated in the multistep transformation of normal squamous esophageal epithelium to Barrett esophagus, dysplasia, and adenocarcinoma, the combinatorial effect of these changes is unknown. By integrating genome-wide DNA methylation,...

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Autors principals: Alvarez, Hector, Opalinska, Joanna, Zhou, Li, Sohal, Davendra, Fazzari, Melissa J., Yu, Yiting, Montagna, Christina, Montgomery, Elizabeth A., Canto, Marcia, Dunbar, Kerry B., Wang, Jean, Roa, Juan Carlos, Mo, Yongkai, Bhagat, Tushar, Ramesh, K. H., Cannizzaro, Linda, Mollenhauer, J., Thompson, Reid F., Suzuki, Masako, Meltzer, Stephen, Melnick, Ari, Greally, John M., Maitra, Anirban, Verma, Amit
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069107/
https://ncbi.nlm.nih.gov/pubmed/21483804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001356
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