Deletion of ARNT/HIF1β in pancreatic beta cells does not impair glucose homeostasis in mice, but is associated with defective glucose sensing ex vivo

AIMS/HYPOTHESIS: It has been suggested that the transcription factor ARNT/HIF1β is critical for maintaining in vivo glucose homeostasis and pancreatic beta cell glucose-stimulated insulin secretion (GSIS). Our goal was to gain more insights into the metabolic defects seen after the loss of ARNT/HIF1...

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Pubblicato in:Diabetologia
Autori principali: Pillai, Renjitha, Paglialunga, Sabina, Hoang, Monica, Cousteils, Katelyn, Prentice, Kacey J., Bombardier, Eric, Huang, Mei, Gonzalez, Frank J., Tupling, A. Russell, Wheeler, Michael B., Joseph, Jamie W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338330/
https://ncbi.nlm.nih.gov/pubmed/26409461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-015-3768-4
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