Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity

Drug-induced kidney injury, largely caused by proximal tubular intoxicants, limits development and clinical use of new and approved drugs. Assessing preclinical nephrotoxicity relies on animal models that are frequently insensitive; thus, potentially novel techniques — including human microphysiolog...

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Vydáno v:JCI Insight
Hlavní autoři: Weber, Elijah J., Lidberg, Kevin A., Wang, Lu, Bammler, Theo K., MacDonald, James W., Li, Mavis J., Redhair, Michelle, Atkins, William M., Tran, Cecilia, Hines, Kelly M., Herron, Josi, Xu, Libin, Monteiro, Maria Beatriz, Ramm, Susanne, Vaidya, Vishal, Vaara, Martti, Vaara, Timo, Himmelfarb, Jonathan, Kelly, Edward J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338315/
https://ncbi.nlm.nih.gov/pubmed/30568031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.123673
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