Methodologies for Improving HDR Efficiency

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9) is a precise genome manipulating technology that can be programmed to induce double-strand break (DSB) in the genome wherever needed. After nuclease cleavage, DSBs can be repaired by non-homologous end joi...

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Bibliografiske detaljer
Udgivet i:Front Genet
Main Authors: Liu, Mingjie, Rehman, Saad, Tang, Xidian, Gu, Kui, Fan, Qinlei, Chen, Dekun, Ma, Wentao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Genetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338032/
https://ncbi.nlm.nih.gov/pubmed/30687381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00691
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