Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans

E-selectin mediates the rolling of circulating leukocytes during inflammatory processes. Previous genome-wide association studies in European and Asian individuals have identified the ABO locus associated with E-selectin levels. Using Trans-Omics for Precision Medicine whole genome sequencing data i...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Polfus, Linda M, Raffield, Laura M, Wheeler, Marsha M, Tracy, Russell P, Lange, Leslie A, Lettre, Guillaume, Miller, Amanda, Correa, Adolfo, Bowler, Russell P, Bis, Joshua C, Salimi, Shabnam, Jenny, Nancy Swords, Pankratz, Nathan, Wang, Biqi, Preuss, Michael H, Zhou, Lisheng, Moscati, Arden, Nadkarni, Girish N, Loos, Ruth J F, Zhong, Xue, Li, Bingshan, Johnsen, Jill M, Nickerson, Deborah A, Reiner, Alex P, Auer, Paul L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Association Studies Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337694/
https://ncbi.nlm.nih.gov/pubmed/30307499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy360
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