Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans

E-selectin mediates the rolling of circulating leukocytes during inflammatory processes. Previous genome-wide association studies in European and Asian individuals have identified the ABO locus associated with E-selectin levels. Using Trans-Omics for Precision Medicine whole genome sequencing data i...

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Dades bibliogràfiques
Publicat a:Hum Mol Genet
Autors principals: Polfus, Linda M, Raffield, Laura M, Wheeler, Marsha M, Tracy, Russell P, Lange, Leslie A, Lettre, Guillaume, Miller, Amanda, Correa, Adolfo, Bowler, Russell P, Bis, Joshua C, Salimi, Shabnam, Jenny, Nancy Swords, Pankratz, Nathan, Wang, Biqi, Preuss, Michael H, Zhou, Lisheng, Moscati, Arden, Nadkarni, Girish N, Loos, Ruth J F, Zhong, Xue, Li, Bingshan, Johnsen, Jill M, Nickerson, Deborah A, Reiner, Alex P, Auer, Paul L
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Association Studies Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337694/
https://ncbi.nlm.nih.gov/pubmed/30307499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy360
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