Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans

E-selectin mediates the rolling of circulating leukocytes during inflammatory processes. Previous genome-wide association studies in European and Asian individuals have identified the ABO locus associated with E-selectin levels. Using Trans-Omics for Precision Medicine whole genome sequencing data i...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Polfus, Linda M, Raffield, Laura M, Wheeler, Marsha M, Tracy, Russell P, Lange, Leslie A, Lettre, Guillaume, Miller, Amanda, Correa, Adolfo, Bowler, Russell P, Bis, Joshua C, Salimi, Shabnam, Jenny, Nancy Swords, Pankratz, Nathan, Wang, Biqi, Preuss, Michael H, Zhou, Lisheng, Moscati, Arden, Nadkarni, Girish N, Loos, Ruth J F, Zhong, Xue, Li, Bingshan, Johnsen, Jill M, Nickerson, Deborah A, Reiner, Alex P, Auer, Paul L
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Association Studies Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337694/
https://ncbi.nlm.nih.gov/pubmed/30307499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy360
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