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Suppression of myopathic lamin mutations by muscle-specific activation of AMPK and modulation of downstream signaling
Laminopathies are diseases caused by dominant mutations in the human LMNA gene encoding A-type lamins. Lamins are intermediate filaments that line the inner nuclear membrane, provide structural support for the nucleus and regulate gene expression. Drosophila melanogaster models of skeletal muscle la...
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| Pubblicato in: | Hum Mol Genet |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6337691/ https://ncbi.nlm.nih.gov/pubmed/30239736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy332 |
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