In Vivo Glycan Engineering via the Mannosidase I Inhibitor (Kifunensine) Improves Efficacy of Rituximab Manufactured in Nicotiana benthamiana Plants

N-glycosylation has been shown to affect the pharmacokinetic properties of several classes of biologics, including monoclonal antibodies, blood factors, and lysosomal enzymes. In the last two decades, N-glycan engineering has been employed to achieve a N-glycosylation profile that is either more con...

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Publicat a:Int J Mol Sci
Autors principals: Kommineni, Vally, Markert, Matthew, Ren, Zhongjie, Palle, Sreenath, Carrillo, Berenice, Deng, Jasmine, Tejeda, Armando, Nandi, Somen, McDonald, Karen A., Marcel, Sylvain, Holtz, Barry
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337617/
https://ncbi.nlm.nih.gov/pubmed/30621113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20010194
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