Metformin Results in Diametrically Opposed Effects by Targeting Non-Stem Cancer Cells but Protecting Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma

Cancer stem cells (CSCs) have been shown as a distinct population of cancer cells strongly implicated with resistance to conventional chemotherapy. Metformin, the most widely prescribed drug for diabetes, was reported to target cancer stem cells in various cancers. In this study, we sought to determ...

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Pubblicato in:Int J Mol Sci
Autori principali: Kuo, Selena Z., Honda, Christine O., Li, Wei Tse, Honda, Thomas K., Kim, Elizabeth, Altuna, Xabier, Abhold, Eric, Wang-Rodriguez, Jessica, Ongkeko, Weg M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337486/
https://ncbi.nlm.nih.gov/pubmed/30621095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20010193
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