MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis

Chondrosarcoma, a heterogeneous malignant bone tumor, commonly produces cartilage matrix, which generally has no response to conventional therapies. Studies have reported that MLN4924, a NEDD8-activating enzyme inhibitor, achieves antitumor effects against numerous malignancies. In this study, the s...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Wu, Meng-Huang, Lee, Ching-Yu, Huang, Tsung-Jen, Huang, Kuo-Yuan, Tang, Chih-Hsin, Liu, Shing-Hwa, Kuo, Kuan-Lin, Kuan, Feng-Che, Lin, Wei-Chou, Shi, Chung-Sheng
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337205/
https://ncbi.nlm.nih.gov/pubmed/30586948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20010072
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