Sepiapterin alleviates impaired gastric nNOS function in spontaneous diabetic female rodents through NRF2 mRNA turnover and miRNA biogenesis pathway

An impaired nitrergic system and altered redox signaling contribute to gastric dysmotility in diabetics. Our earlier studies show that NF-E2-related factor 2 (NRF2) and phase II antioxidant enzymes play a vital role in gastric neuronal nitric oxide synthase (nNOS) function. This study aims to invest...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Gangula, Pandu R., Challagundla, Kishore B., Ravella, Kalpana, Mukhopadhyay, Sutapa, Chinnathambi, Vijayakumar, Mittal, Mukul K., Sekhar, K. Raja, Sampath, Chethan
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336949/
https://ncbi.nlm.nih.gov/pubmed/30285465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00152.2018
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