Sepiapterin alleviates impaired gastric nNOS function in spontaneous diabetic female rodents through NRF2 mRNA turnover and miRNA biogenesis pathway

An impaired nitrergic system and altered redox signaling contribute to gastric dysmotility in diabetics. Our earlier studies show that NF-E2-related factor 2 (NRF2) and phase II antioxidant enzymes play a vital role in gastric neuronal nitric oxide synthase (nNOS) function. This study aims to invest...

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Publicat a:Am J Physiol Gastrointest Liver Physiol
Autors principals: Gangula, Pandu R., Challagundla, Kishore B., Ravella, Kalpana, Mukhopadhyay, Sutapa, Chinnathambi, Vijayakumar, Mittal, Mukul K., Sekhar, K. Raja, Sampath, Chethan
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336949/
https://ncbi.nlm.nih.gov/pubmed/30285465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00152.2018
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