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Menin Upregulates FOXO1 Protein Stability by Repressing Skp2-Mediated Degradation in β Cells
OBJECTIVES: Menin, a chromatin binding protein, interacts with various epigenetic regulators to regulate gene transcription, whereas forkhead box protein O1 (FOXO1) is a transcription factor that can be regulated by multiple signaling pathways. Both menin and FOXO1 are crucial regulators of β-cell f...
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| Veröffentlicht in: | Pancreas |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Lippincott Williams & Wilkins
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6336489/ https://ncbi.nlm.nih.gov/pubmed/30629029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000001239 |
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