Menin Upregulates FOXO1 Protein Stability by Repressing Skp2-Mediated Degradation in β Cells

OBJECTIVES: Menin, a chromatin binding protein, interacts with various epigenetic regulators to regulate gene transcription, whereas forkhead box protein O1 (FOXO1) is a transcription factor that can be regulated by multiple signaling pathways. Both menin and FOXO1 are crucial regulators of β-cell f...

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Bibliografiske detaljer
Udgivet i:Pancreas
Main Authors: Jiang, Zongzhe, Xing, Bowen, Feng, Zijie, Ma, Jian, Ma, Xiaosong, Hua, Xianxin
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2019
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336489/
https://ncbi.nlm.nih.gov/pubmed/30629029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000001239
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