An interferon-driven oxysterol-based defense against tumor-derived extracellular vesicles

Tumor-derived extracellular vesicles (TEV) “educate” healthy cells to promote metastases. We found that melanoma TEV downregulated type I interferon (IFN) receptor and expression of IFN-inducible cholesterol 25-hydroxylase (CH25H). CH25H produces 25-hydroxycholesterol, which inhibited TEV uptake. Lo...

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Publicado no:Cancer Cell
Main Authors: Ortiz, Angelica, Gui, Jun, Zahedi, Farima, Yu, Pengfei, Cho, Christina, Bhattacharya, Sabyasachi, Carbone, Christopher J., Yu, Qiujing, Katlinski, Kanstantsin V., Katlinskaya, Yuliya V., Handa, Simran, Haas, Victor, Volk, Susan W., Brice, Angela K., Wals, Kim, Matheson, Nicholas J., Antrobus, Robin, Ludwig, Sonja, Whiteside, Theresa L., Sander, Cindy, Tarhini, Ahmad A., Kirkwood, John M., Lehner, Paul J., Guo, Wei, Rui, Hallgeir, Minn, Andy J., Koumenis, Constantinos, Diehl, J. Alan, Fuchs, Serge Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336114/
https://ncbi.nlm.nih.gov/pubmed/30645975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.12.001
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