An interferon-driven oxysterol-based defense against tumor-derived extracellular vesicles

Tumor-derived extracellular vesicles (TEV) “educate” healthy cells to promote metastases. We found that melanoma TEV downregulated type I interferon (IFN) receptor and expression of IFN-inducible cholesterol 25-hydroxylase (CH25H). CH25H produces 25-hydroxycholesterol, which inhibited TEV uptake. Lo...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cancer Cell
मुख्य लेखकों: Ortiz, Angelica, Gui, Jun, Zahedi, Farima, Yu, Pengfei, Cho, Christina, Bhattacharya, Sabyasachi, Carbone, Christopher J., Yu, Qiujing, Katlinski, Kanstantsin V., Katlinskaya, Yuliya V., Handa, Simran, Haas, Victor, Volk, Susan W., Brice, Angela K., Wals, Kim, Matheson, Nicholas J., Antrobus, Robin, Ludwig, Sonja, Whiteside, Theresa L., Sander, Cindy, Tarhini, Ahmad A., Kirkwood, John M., Lehner, Paul J., Guo, Wei, Rui, Hallgeir, Minn, Andy J., Koumenis, Constantinos, Diehl, J. Alan, Fuchs, Serge Y.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336114/
https://ncbi.nlm.nih.gov/pubmed/30645975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.12.001
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