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Foxo1 nucleo-cytoplasmic distribution and unidirectional nuclear influx are the same in nuclei in a single skeletal muscle fiber but vary between fibers

Foxo transcription factors promote protein breakdown and atrophy of skeletal muscle fibers. Foxo transcriptional effectiveness is largely determined by phosphorylation-dependent nucleo-cytoplasmic shuttling. Imaging Foxo1-green fluorescent protein (GFP) over time in 124 nuclei in 68 multinucleated a...

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Bibliografske podrobnosti
izdano v:Am J Physiol Cell Physiol
Main Authors: Liu, Yewei, Russell, Sarah J., Schneider, Martin F.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335016/
https://ncbi.nlm.nih.gov/pubmed/29187365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00168.2017
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