Mathematical modeling reveals modulation of both nuclear influx and efflux of Foxo1 by the IGF-I/PI3K/Akt pathway in skeletal muscle fibers

Foxo family transcription factors contribute to muscle atrophy by promoting transcription of the ubiquitin ligases muscle-specific RING finger protein and muscle atrophy F-box/atrogin-1. Foxo transcriptional effectiveness is largely determined by its nuclear-cytoplasmic distribution, with unphosphor...

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Detaylı Bibliyografya
Asıl Yazarlar: Wimmer, Robert J., Liu, Yewei, Schachter, Tova Neustadt, Stonko, David P., Peercy, Bradford E., Schneider, Martin F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2014
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948977/
https://ncbi.nlm.nih.gov/pubmed/24429066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00338.2013
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