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Phase 1 Study of the Antimesothelin Immunotoxin SS1P in Combination With Pemetrexed and Cisplatin for Front-Line Therapy of Pleural Mesothelioma and Correlation of Tumor Response With Serum Mesothelin, Megakaryocyte Potentiating Factor, and Cancer Antigen 125

BACKGROUND: The primary objective of this study was to determine the safety and maximum tolerated dose (MTD) of the antimesothelin immunotoxin SS1(dsFv)PE38 (SS1P) (a recombinant antimesothelin immunotoxin consisting of a murine antimesothelin variable antibody fragment [Fv] linked to PE38, a trunca...

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Detalles Bibliográficos
Publicado en:Cancer
Main Authors: Hassan, Raffit, Sharon, Elad, Thomas, Anish, Zhang, Jingli, Ling, Alexander, Miettinen, Markku, Kreitman, Robert J., Steinberg, Seth M., Hollevoet, Kevin, Pastan, Ira
Formato: Artigo
Idioma:Inglês
Publicado: 2014
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334650/
https://ncbi.nlm.nih.gov/pubmed/24989332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28875
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