Discovery of peptide ligands targeting a specific ubiquitin-like domain–binding site in the deubiquitinase USP11

Ubiquitin-specific proteases (USPs) reverse ubiquitination and regulate virtually all cellular processes. Defined noncatalytic domains in USP4 and USP15 are known to interact with E3 ligases and substrate recruitment factors. No such interactions have been reported for these domains in the paralog U...

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Vydáno v:J Biol Chem
Hlavní autoři: Spiliotopoulos, Anastasios, Blokpoel Ferreras, Lia, Densham, Ruth M., Caulton, Simon G., Maddison, Ben C., Morris, Joanna R., Dixon, James E., Gough, Kevin C., Dreveny, Ingrid
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333900/
https://ncbi.nlm.nih.gov/pubmed/30373771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004469
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