USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168*

During DNA damage response (DDR), histone ubiquitination by RNF168 is a critical event, which orchestrates the recruitment of downstream DDR factors, e.g. BRCA1 and 53BP1. Here, we report USP7 deubiquitinase regulates the stability of RNF168. We showed that USP7 disruption impairs H2A and ultraviole...

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Publicat a:Cell Cycle
Autors principals: Zhu, Qianzheng, Sharma, Nidhi, He, Jinshan, Wani, Gulzar, Wani, Altaf A
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613370/
https://ncbi.nlm.nih.gov/pubmed/25894431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1007785
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