Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin

Cockayne syndrome group A and B (CSB) proteins act in transcription-coupled repair, a subpathway of nucleotide excision repair. Here we demonstrate that valosin-containing protein (VCP)/p97 segregase functions in ultraviolet radiation (UVR)-induced ubiquitin-mediated CSB degradation. We show that VC...

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Vydáno v:J Biol Chem
Hlavní autoři: He, Jinshan, Zhu, Qianzheng, Wani, Gulzar, Sharma, Nidhi, Wani, Altaf A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817171/
https://ncbi.nlm.nih.gov/pubmed/26826127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705350
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