Ubiquitin-specific Protease 7 Regulates Nucleotide Excision Repair through Deubiquitinating XPC Protein and Preventing XPC Protein from Undergoing Ultraviolet Light-induced and VCP/p97 Protein-regulated Proteolysis

Ubiquitin specific protease 7 (USP7) is a known deubiquitinating enzyme for tumor suppressor p53 and its downstream regulator, E3 ubiquitin ligase Mdm2. Here we report that USP7 regulates nucleotide excision repair (NER) via deubiquitinating xeroderma pigmentosum complementation group C (XPC) protei...

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Bibliographische Detailangaben
Hauptverfasser: He, Jinshan, Zhu, Qianzheng, Wani, Gulzar, Sharma, Nidhi, Han, Chunhua, Qian, Jiang, Pentz, Kyle, Wang, Qi-en, Wani, Altaf A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175359/
https://ncbi.nlm.nih.gov/pubmed/25118285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589812
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