Ubiquitin-specific Protease 7 Regulates Nucleotide Excision Repair through Deubiquitinating XPC Protein and Preventing XPC Protein from Undergoing Ultraviolet Light-induced and VCP/p97 Protein-regulated Proteolysis

Ubiquitin specific protease 7 (USP7) is a known deubiquitinating enzyme for tumor suppressor p53 and its downstream regulator, E3 ubiquitin ligase Mdm2. Here we report that USP7 regulates nucleotide excision repair (NER) via deubiquitinating xeroderma pigmentosum complementation group C (XPC) protei...

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Detalhes bibliográficos
Main Authors: He, Jinshan, Zhu, Qianzheng, Wani, Gulzar, Sharma, Nidhi, Han, Chunhua, Qian, Jiang, Pentz, Kyle, Wang, Qi-en, Wani, Altaf A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175359/
https://ncbi.nlm.nih.gov/pubmed/25118285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589812
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