Ubiquitin-specific Protease 7 Regulates Nucleotide Excision Repair through Deubiquitinating XPC Protein and Preventing XPC Protein from Undergoing Ultraviolet Light-induced and VCP/p97 Protein-regulated Proteolysis

Ubiquitin specific protease 7 (USP7) is a known deubiquitinating enzyme for tumor suppressor p53 and its downstream regulator, E3 ubiquitin ligase Mdm2. Here we report that USP7 regulates nucleotide excision repair (NER) via deubiquitinating xeroderma pigmentosum complementation group C (XPC) protei...

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Autors principals: He, Jinshan, Zhu, Qianzheng, Wani, Gulzar, Sharma, Nidhi, Han, Chunhua, Qian, Jiang, Pentz, Kyle, Wang, Qi-en, Wani, Altaf A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
DNA and Chromosomes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175359/
https://ncbi.nlm.nih.gov/pubmed/25118285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589812
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