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Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection
BACKGROUND: Sterile alpha motif and histidine/aspartic acid domain-containing protein (SAMHD1) is a dNTP triphosphorylase that reduces cellular dNTP levels in non-dividing cells, such as macrophages. Since dNTPs are required for reverse transcription, HIV-2 and most SIVs encode a Vpx protein that pr...
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| Udgivet i: | Pathog Immun |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Pathogens and Immunity
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6333473/ https://ncbi.nlm.nih.gov/pubmed/30656243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.20411/pai.v3i2.263 |
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