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Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages
BACKGROUND: SAM domain and HD domain containing protein 1 (SAMHD1) is a host anti-HIV-1 restriction factor known to suppress viral reverse transcription in nondividing myeloid cells by its dNTP triphosphorylase activity that depletes cellular dNTPs. However, HIV-2 and some SIV strains rapidly replic...
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| 發表在: | Retrovirology |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6186296/ https://ncbi.nlm.nih.gov/pubmed/30316304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-018-0452-z |
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