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Host SAMHD1 Protein Promotes HIV-1 Recombination in Macrophages
Template switching can occur during the reverse transcription of HIV-1. Deoxynucleotide triphosphate (dNTP) concentrations have been biochemically shown to impact HIV-1 reverse transcriptase (RT)-mediated strand transfer. Lowering the dNTP concentrations promotes RT pausing and RNA template degradat...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3908385/ https://ncbi.nlm.nih.gov/pubmed/24352659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C113.522326 |
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