Bioactivity of AAV2-Neurturin Gene Therapy (CERE-120): Differences Between Parkinson’s Disease and Nonhuman Primate Brains

BACKGROUND: AAV2-neurturin (CERE-120) is designed to deliver the neurotrophic-factor, neurturin, to the striatum to restore and protect degenerating nigrostriatal neurons in Parkinson’s disease (PD). A common hypothesis is that following expression in the striatum, neurotrophic-factors like neurturi...

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Detalhes bibliográficos
Publicado no:Mov Disord
Main Authors: Bartus, Raymond T., Herzog, Christopher D., Chu, Yaping, Wilson, Alistair, Brown, Lamar, Siffert, Joao, Johnson, Eugene M., Olanow, C. Warren, Mufson, Elliott J., Kordower, Jeffrey H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333467/
https://ncbi.nlm.nih.gov/pubmed/21322017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.23442
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