Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients

OBJECTIVE: In an effort to account for deficiencies in axonal transport that limit the effectiveness of neurotrophic factors, this study tested the safety and feasibility, in moderately advanced Parkinson disease (PD), of bilaterally administering the gene therapy vector AAV2-neurturin (CERE-120) to...

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Detalhes bibliográficos
Main Authors: Bartus, Raymond T., Baumann, Tiffany L., Siffert, Joao, Herzog, Christopher D., Alterman, Ron, Boulis, Nicholas, Turner, Dennis A., Stacy, Mark, Lang, Anthony E., Lozano, Andres M., Olanow, C. Warren
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716474/
https://ncbi.nlm.nih.gov/pubmed/23576625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3182904faa
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