Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients

OBJECTIVE: In an effort to account for deficiencies in axonal transport that limit the effectiveness of neurotrophic factors, this study tested the safety and feasibility, in moderately advanced Parkinson disease (PD), of bilaterally administering the gene therapy vector AAV2-neurturin (CERE-120) to...

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Détails bibliographiques
Auteurs principaux: Bartus, Raymond T., Baumann, Tiffany L., Siffert, Joao, Herzog, Christopher D., Alterman, Ron, Boulis, Nicholas, Turner, Dennis A., Stacy, Mark, Lang, Anthony E., Lozano, Andres M., Olanow, C. Warren
Format: Artigo
Langue:Inglês
Publié: Lippincott Williams & Wilkins 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716474/
https://ncbi.nlm.nih.gov/pubmed/23576625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3182904faa
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