MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca(2+) communication: a dead end in cancer cells

The interruption of endoplasmic reticulum (ER)-mitochondrial Ca(2+) communication induces a bioenergetic crisis characterized by an increase of MTOR-independent AMPK-dependent macroautophagic/autophagic flux, which is not sufficient to reestablish the metabolic and energetic homeostasis in cancer ce...

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Detalles Bibliográficos
Publicado en:Autophagy
Autores principales: Ahumada-Castro, Ulises, Silva-Pavez, Eduardo, Lovy, Alenka, Pardo, Evelyn, Molgό, Jordi, Cárdenas, César
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2018
Materias:
Commentary
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333456/
https://ncbi.nlm.nih.gov/pubmed/30351219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1537769
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