Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo

Human Atg4 homologs are cysteine proteases, which play key roles in the macroautophagy/autophagy process by cleaving Atg8 homologs for conjugation to lipid membranes and for deconjugation of Atg8 homologs from membranes. Expression of ATG4B is significantly increased in colorectal cancer cells compa...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Fu, Yuanyuan, Hong, Liang, Xu, Jiecheng, Zhong, Guoping, Gu, Qiong, Gu, Qianqian, Guan, Yanping, Zheng, Xueping, Dai, Qi, Luo, Xia, Liu, Cui, Huang, Zhiying, Yin, Xiao-Ming, Liu, Peiqing, Li, Min
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper - Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333450/
https://ncbi.nlm.nih.gov/pubmed/30176161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1517073
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