Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo

Human Atg4 homologs are cysteine proteases, which play key roles in the macroautophagy/autophagy process by cleaving Atg8 homologs for conjugation to lipid membranes and for deconjugation of Atg8 homologs from membranes. Expression of ATG4B is significantly increased in colorectal cancer cells compa...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Autophagy
Egile Nagusiak: Fu, Yuanyuan, Hong, Liang, Xu, Jiecheng, Zhong, Guoping, Gu, Qiong, Gu, Qianqian, Guan, Yanping, Zheng, Xueping, Dai, Qi, Luo, Xia, Liu, Cui, Huang, Zhiying, Yin, Xiao-Ming, Liu, Peiqing, Li, Min
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2018
Gaiak:
Research Paper - Basic Science
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333450/
https://ncbi.nlm.nih.gov/pubmed/30176161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1517073
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