Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo

Human Atg4 homologs are cysteine proteases, which play key roles in the macroautophagy/autophagy process by cleaving Atg8 homologs for conjugation to lipid membranes and for deconjugation of Atg8 homologs from membranes. Expression of ATG4B is significantly increased in colorectal cancer cells compa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Autophagy
Prif Awduron: Fu, Yuanyuan, Hong, Liang, Xu, Jiecheng, Zhong, Guoping, Gu, Qiong, Gu, Qianqian, Guan, Yanping, Zheng, Xueping, Dai, Qi, Luo, Xia, Liu, Cui, Huang, Zhiying, Yin, Xiao-Ming, Liu, Peiqing, Li, Min
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2018
Pynciau:
Research Paper - Basic Science
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333450/
https://ncbi.nlm.nih.gov/pubmed/30176161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1517073
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