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Cbl exposes its RING finger
The Cbl family of RING finger ubiquitin ligases regulates signaling in many systems. Two new studies provide a structural basis for how phosphorylation of a specific tyrosine in the Cbl proteins enhances their ubiquitin ligase activity, giving insight into how ubiquitination by Cbl proteins is restr...
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| Published in: | Nat Struct Mol Biol |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6333313/ https://ncbi.nlm.nih.gov/pubmed/22301873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2241 |
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