Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells

INTRODUCTION: Many human breast cancers overexpress the E3 ubiquitin ligase MDM2 and its homolog MDMX. Expression of MDM2 and MDMX occurs in estrogen receptor α-positive (ERα(+)) breast cancer and triple-negative breast cancer (TNBC). There are p53-independent influences of MDM2 and MDMX, and 80% of...

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Publicat a:Breast Cancer Res
Autors principals: Gao, Chong, Xiao, Gu, Piersigilli, Alessandra, Gou, Jiangtao, Ogunwobi, Olorunseun, Bargonetti, Jill
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6332579/
https://ncbi.nlm.nih.gov/pubmed/30642351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-018-1094-8
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