A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation

INTRODUCTION: Estrogen receptor positive breast cancers often have high levels of Mdm2. We investigated if estrogen signaling in such breast cancers occurred through an Mdm2 mediated pathway with subsequent inactivation of p53. METHODS: We examined the effect of long-term 17β-estradiol (E2) treatmen...

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Main Authors: Brekman, Angelika, Singh, Kathryn E, Polotskaia, Alla, Kundu, Nandini, Bargonetti, Jill
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109566/
https://ncbi.nlm.nih.gov/pubmed/21223569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2804
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