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8-amino-adenosine Activates p53-Independent Cell Death of Metastatic Breast Cancers
8-amino-adenosine (8-NH(2)-Ado) is a ribose sugar nucleoside analogue that reduces cellular ATP levels and inhibits mRNA synthesis. Estrogen receptor negative (ER−), metastatic breast cancers often contain mutant p53; therefore we asked if 8-NH(2)-Ado could kill breast cancer cells without activatin...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535282/ https://ncbi.nlm.nih.gov/pubmed/22973058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0085 |
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